By Ruth Anne Eatock (Editor), Richard R. Fay (Editor), Arthur N. Popper (Editor)

Vertebrate Hair Cells offers a present review of the mechanosensory receptor cells of the vertebrate internal ear. every one bankruptcy is written through experimentalists lively in exploring a specific set of questions in a facet of hair telephone functionality, together with improvement, transduction, and synaptic transmission. Experimental approaches described comprise molecular, genetic, ultrastructural, biophysical and computational. therefore, every one bankruptcy covers not only what we all know, yet how we have now discovered it and the consequences for destiny paintings. The experimental concentration differentiates this e-book from basic textbooks and objectives a sophisticated viewers, from senior undergraduates via to scientists within the box of hair phone learn.

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Extra info for Vertebrate Hair Cells (Springer Handbook of Auditory Research)

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These vertical bands of Math1-expressing cells may be bipotential progenitors, a subset of which become hair cells (Lanford et al. 2000). Alternatively, they may be vertical stacks of hair cells that then spread out along the length of the cochlea as it elongates, by a process that has been referred to as radial intercalation (Chen et al. 2002). After birth, the expression of Math1 decreases, in both the cochlea and the vestibular system (Shailam et al. 1999; Lanford et al. 2000). Math1 null mutant mice have been produced by replacing the coding region of Math1 with the gene encoding β-galactosidase.

2000). In the mouse cochlea, Lfng is expressed in the cells that immediately surround the IHCs and the OHCs at E18, that is, by the inner phalangeal cells, Deiters cells and the outer pillar cells, but not by the inner pillar cells (Zhang et al. 2000). 5, before the appearance of sensory patches in the inner ear, so it has not been possible to assess hair-cell differentiation in these mice. However, heterozygous Notch1ϩ/Ϫ mice are viable and a significant increase is observed in the numbers of regions along the cochlea where there are four instead of three rows of outer hair cells (Zhang et al.

2000). Alternatively, they may be vertical stacks of hair cells that then spread out along the length of the cochlea as it elongates, by a process that has been referred to as radial intercalation (Chen et al. 2002). After birth, the expression of Math1 decreases, in both the cochlea and the vestibular system (Shailam et al. 1999; Lanford et al. 2000). Math1 null mutant mice have been produced by replacing the coding region of Math1 with the gene encoding β-galactosidase. Hair cells are completely absent from the inner ears of these mice (Bermingham et al.

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