By R. L. Balster (auth.), F. C. Colpaert Ph.D, R. L. Balster Ph.D (eds.)

In this publication the newest facts to be had on transduction mechanisms of drug stimuli are provided. a typical topic underlying the bankruptcy during this quantity is the popularity that medicinal drugs can act as stimuli, in a lot an identical demeanour as exterior occasions do. therefore, the papers specialize in the mechanisms in which those stimuli are transduced at assorted degrees of research, resembling the behavioral, pharmacological, and molecular degrees. a few chapters talk about the mechanisms of transduction of the discriminative results of numerous vital periods of gear, whereas others take care of the equipment and examine thoughts in which those mechanisms may be analyzed. jointly, the papers during this quantity replicate the present prestige of data within the quickly increasing box of behavioral pharmacology.

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2 Testing Procedures Three kinds of tests were conducted: In dose-response determinations, rats were tested with a wide range of doses ofSKF 38393 or Ly 171555. In substitution (generalization) tests, novel drugs were given 15-30 min prior to testing instead of the training drug and, in combination (antagonism) tests, rats were given various doses of putatively selective neurotransmitter antagonists 60 min prior to testing as well as the training drug (SKF 38393 or Ly 171555), 15-30 min prior to testing.

1986). g. Sloan et al. 1984) and there is some recent evidence that ganglion-blockers can distinguish between them (Collins et al. 1986). The fact that the nicotine cue has different characteristics at different training doses is also compatible with the presence of receptor subtypes (Stolerman et al. 1984), although such an interpretation of the data is very speculative. The present information does-not enable conclusions to be reached about whether similar subtypes of receptor may mediate the discriminative and other behavioural effects of nicotine.

Psychopharmacology 80:209-213 Friedman RA, Barrett RJ, Sanders-Bush E (1984) Discriminative stimulus properties of quipazine: mediation by serotonin-2 binding sites. J Pharmacol Exp Ther 228:628-635 Friedman RL, Sanders-Bush E, Barrett RL (1985) Clozapine blocks disruptive and discriminative stimulus effects of quipazine. Eur J Pharmacoll06:191-193 Fuller RW, Mason NR (1979) Structure-activity relationships in the actions of I-phenylpiperazines on brain serotonin receptors. In: Haber B, Gabay S, Issidorides MR, Alivisatos SGA (eds) Serotonin: current aspects of neurochemistry and function.

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