By Henry Margenau, George Moseley Murphy

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2 demonstrates that none of the applied doses of (−)-BPAP was capable of changing the learning performance of rats in the shuttle box. In accord with the findings on cultured rat cortical neurons, the in vivo experiments confirmed that (−)-BPAP, the presently known most potent synthetic mesencephalic enhancer substance, is devoid of a specific enhancer effect on the cortical neurons. The second study of the enhancer effect on cultured telencephalic neurons was performed on cortical cells from 8-day-old chicken embryos (Lohman brown hybrid).

2001). The in vivo dose-dependent enhancer effect of (−)-BPAP is illustrated on noradrenergic (Fig. 7), dopaminergic (Fig. 8), and serotonergic neurons (Fig. 9), respectively. A comparison of the enhancer effect of (−)-BPAP and (−)-deprenyl shows 1. The substantially higher potency of (−)-BPAP than (−)-deprenyl in enhancing the activity of catecholaminergic neurons 2. The characteristic dose-dependency of the enhancer effect of (−)-BPAP on noradrenergic (Fig. 7) and serotonergic neurons (Fig. 9), and 3.

8), and serotonergic neurons (Fig. 9), respectively. A comparison of the enhancer effect of (−)-BPAP and (−)-deprenyl shows 1. The substantially higher potency of (−)-BPAP than (−)-deprenyl in enhancing the activity of catecholaminergic neurons 2. The characteristic dose-dependency of the enhancer effect of (−)-BPAP on noradrenergic (Fig. 7) and serotonergic neurons (Fig. 9), and 3. The highly potent in vivo enhancer effect of (−)-BPAP on serotonergic neurons (Fig. 9) and the lack of this effect on the part of (−)-deprenyl (Fig.

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