By Robert A. Lamb (auth.), Robert M. Krug (eds.)

Influenza virus is a vital human pathogen, often inflicting frequent affliction and an important demise. a lot has been realized concerning the constitution of the virus, its genetic version, its mode of gene expression and replication, and its interplay with the host immu­ nologic process. this information has the potential for resulting in ap­ proaches for the keep an eye on of influenza virus. furthermore, examine on influ­ enza virus has resulted in very important advances in eukaryotic molecular and mobile biology and in immunology. a tremendous concentration of this e-book is the molecular biology of influenza virus. the 1st bankruptcy, which serves as an creation, describes the constitution of every of the genomic RNA segments and their encoded seasoned­ teins. the second one bankruptcy discusses the molecular mechanisms concerned about the expression and replication of the viral genome. as well as different topics, this bankruptcy bargains with some of the most unique positive factors of influenza virus, particularly the original mechanism wherein viral messenger RNA synthesis is initiated via primers deaved from newly synthesized host-cell RNAs within the nudeus. one of the most important accomplish­ ments in influenza virus examine has been the delineation of the 3­ dimensional constitution of the 2 floor glycoproteins of the virus, the hemagglutinin and neuraminidase. This has supplied a structural foundation for mapping either the antigenic websites and the areas thinking about the key organic capabilities of those molecules.

Show description

Read Online or Download The Influenza Viruses PDF

Best nonfiction_8 books

Thermal Conductivity 20

The foreign Thermal Conductivity convention was once began in 1961 with the initiative of Mr. Charles F. Lucks and grew out of the wishes of researchers within the box. The meetings have been held every year from 1961 to 1973 and feature been held biennially when you consider that 1975 while our heart for Informa­ tion and Numerical info research and Synthesis (CINDAS) of Purdue college turned the everlasting Sponsor of the meetings.

New Methods for Polymer Synthesis

The artwork and technology of macromolecular structure relies on synthesis, research, processing, and assessment of actual homes of polymers. The turning out to be specificity of obtainable artificial equipment and the expanding refinement of analytical and actual research are steadily offering a deeper perception into structure-property relationships of polymers, upon which many functions may be dependent.

Animal Mind — Human Mind: Report of the Dahlem Workshop on Animal Mind — Human Mind, Berlin 1981, March 22–27

The oleic acid on a dwell and wriggling sister or mom and chorus from evicting her from our hive. yet does the ensue­ rence of unintelligent habit suffice to illustrate the entire absence of psychological event less than any conditions? Ethologists from a few far-off galaxy may well simply determine ex­ amples of silly and maladaptive habit in our personal species.

Global Climate Change and Freshwater Ecosystems

Worldwide weather switch is a walk in the park. The Earth's weather hasn't ever remained static for lengthy and the possibility for human-accelerated weather swap within the close to destiny looks most likely. Freshwater structures are in detail attached to weather in numerous methods: they might effect international atmospheric tactics affecting weather; they're delicate early symptoms of weather swap simply because they combine the atmospheric and terrestrial occasions taking place of their catchments; and, after all, they are going to be laid low with weather swap.

Extra resources for The Influenza Viruses

Example text

The hydrophobic N-terminus of HA2 is separated from the C-terminus of HA l by 22 A, indicating that a conformational change accompanied the eleavage of the two molecules. This hydrophobic fusion peptide in each monomer is tucked into the trimer interface ~35 A from the lipid bilayer. , 1981; Wiley and Skehel, 1987). , 1988). Six N-linked carbohydrate chains are attached to HA l and one chain to HA2. All the carbohydrate chains are of the complex type, except for two on HAll which are of the high mannose type (Ward and Dopheide, 1980).

1980), the HA l and HA2 identity is 35% and 53%, respectively. Thus, the B HA sequence is somewhat removed from, but stiIl homologous to, the influenza A HA sequences. , 1983a). H. Influenza e Virus Glycoprotein In contrast to the two distinet glycoproteins of influenza A and B viruses, which exhibit HA and NA aetivities, only a single type of glycoprotein has been deteeted in influenza C virions. This glyeoprotein displays receptor-binding aetivity for 9-0-acetyl-N-aeetylneuraminic GENES AND PROTEINS OF INFLUENZA VIRUSES 21 acid, a penetration (fusion) funetion, and a reeeptor-destroying aetivity, whieh is a neuraminate-O-aeetylesterase.

A. 18) eatalyzes the eleavage of the a-ketosidie linkage between a terrninal sialie acid and an adjaeent D-galaetose or D-galaetosamine (Gottsehalk, 1957). The funetional role of NA in viru s replieation has not been established with great eertainty, although it appears to be related to the ability of the virus to free itself from sialie aeid-eontaining struetures. NA aetivity may permit transport of the virus through mucin present in the respiratory traet, enabling the virus to find its way to the target epithelial eelIs.

Download PDF sample

Rated 4.98 of 5 – based on 18 votes