By Fred Snyder, Ten-ching Lee, Robert L. Wykle (auth.), Anthony N. Martonosi (eds.)

In the 1st variation of The Enzymes of organic Membranes, released in 4 volumes in 1976, we accumulated the mass of commonly scattered info on membrane-linked enzymes and metabolic procedures as much as approximately 1975. This was once a interval of transition from the romantic part of membrane biochemistry, preoccupied with conceptual advancements and the overall homes of membranes, to an period of mounting curiosity within the particular homes of membrane-linked enzymes analyzed from the viewpoints of modem enzymology. the extent of class in quite a few parts of membrane learn assorted commonly; the constructions of cytochrome c and cytochrome b have been recognized s to atomic aspect, whereas the vast majority of membrane-linked enzymes had now not even been remoted. within the intervening 8 years our wisdom of membrane-linked enzymes ex­ panded past the wildest expectancies. the aim of the second one variation of The Enzymes of organic Membranes is to list those advancements. the 1st quantity describes the actual and chemical concepts utilized in the research of the constitution and dynamics of organic membranes. within the moment quantity the enzymes and met­ abolic platforms that perform the biosynthesis of cellphone and membrane elements are mentioned. The 3rd and fourth volumes overview fresh advancements in lively delivery, oxidative phosphorylation and photosynthesis.

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1976). , 1977, 1978, 1981). , 1982). , 1972a; Wykle and Lockmiller, 1975; Wykle and Schremmer, 1979; Paltauf and Holasek, 1973). Since all the enzymatic studies indicate that only l-alkyl-2-acyl-GPE is desaturated, it appears that the higher rate of synthesis obtained with the lyso precursor is related to differences in uptake by the cells or positioning of the substrates for accessibility to the enzyme in the cell membranes (Wykle and Schremmer, 1979). e CLYCEROUPIDS AND THEIR BIOACTIVE SPECIES 25 The desaturation of l-alkyl-2-lyso-GPC or l-alkal-2-acyl-GPC has not been reported.

Solubilized alkyl-DHAP synthase is labile unless ethylene glycol or glycerol (20%) is added as a stabilizer. Such a preparation has been successfully purified by a multistep chromatographic procedure developed by Brown and Snyder (1982). This involved successive column elutions from DEAE-cellulose, QAE-Sephadex, Matrex Red, and hydroxylapatite. A new rapid assay method with DEAE-cellulose disks facilitates monitoring the enzyme activity during purification. Acyl- or alkyl-DHAP oxidoreductase, DHAP acyltransferase, alkyl-DHAP phosphohydrolase, and a DNFB-insensitive acyl-DHAP acylhydrolase activities were removed during purification, whereas the DNFB-sensitive acyl hydrolase was still associated with this 97-fold purified preparation of alkyl-DHAP synthase (Brown and Snyder, 1982).

1966; Holloway and Katz, 1972; Oshino and Omuura, 1973) and suggest that the cytochrome bs-dependent microsomal electron transport system is responsible for plasmalogen synthesis. Paltauf et al. (l974b) concluded from studies with an antibody to cytochrome bs that plasmalogen synthesis by hog spleen microsomes requires cytochrome bs . Brain microsomes were shown to synthesize ethanolamine plasmalogens by the same system as the tumor and spleen (Wykle and Lockmiller, 1975). Thus, brain appears to desaturate l-alkyl-2-acyl-GPE by the cytochrome bs-requiring electron transport system.

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