By D. Spandidos

Lawsuits of the workshop held Nov. 1988. Ras genes represent a major relations one of the fifty oncogenes which were found thus far, they usually give a contribution considerably to the human tumor burden in view that round 70% of human tumors have an elevated point of ras gene product and forty% hold a m

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48:4459 (1988). O. Fasano, D. Birnbaum, L. Fdlulrl, J. Fogh ani M. Wigler. New hunan transfonniqr gene detected by a tUITOrigenicity assay. M:>l. Cell. Biol. 4:1695 (1984). ~ Papadimitriou, M. Yiagnisis, G. A. Spandidos. Inmunohistochemical analysis of the ras oncogene protein product in human thyroid neoplasms. Anticancer Res. In press. E. J. Davis, B. M. Scolnick. MJmclonal antibodies to the p21 products of the transforming gene of Harvey nurine sarcare. virus of the cellular ras gene family.

S contained higher levels ~ p21 as catpared to adjacent oo:rnal tissue. p21 the ani of DISClJSSION It has r011 becare clear that qualitative arrl quantitative changes in the expression of oncogenes could be ilrportant in diagnosis arrl prognosis of specific types of nalignant tunors. OUr fitrlings suggest that ras p21 is expressed at elevated levels in the rrajority of thyroid carcimrras arrl adeiJCilas. It activaticn by has been fourrl carcinaras arrl an ras genes orx:ogenes (H-, is of interest that a high frequency of ras on::ogene point nutation in benign arrl rralignant htman thyroid tunors (11, 15).

Oscier, D. F. ; San Francisco, USA The ras gene family, H-ras, K-ras and N-ras, code for 2lkD proteins that have GTPase activity and have been implicated in the control of cell proliferation . Mutations in these genes give rise to abnormal protein products that have the capacity to transform certain cells to a malignant phenotype. l985; Hirai et al. 1985). Activation of these genes has been associated with mutations in codons 12/13 or codon 61 and lesions of this type have recently been described in MDS.

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