By L.-D. Leder (auth.), Privatdozent Dr. Johannes Ring, Prof. Dr. Günter Burg (eds.)
From the 1st to the 3rd of August, 1980, a global sym posium entitled "New developments in hypersensitive reaction" was once held in Munich, backed through the Ludwig-Maximilian collage, Munich, in cooperation with the German Society for allergic reaction and Immunity examine and the eu Society for Dermatological study. The symposium pursued major objectives: to convey hypersensitivity orientated colleagues from a variety of specialties akin to dermatology, otorhinolaryngology, pediatrics, inner medication, immunology, and pulmonology jointly for interdisciplinary contacts and dis cussions; and to draw across the world identified specialists so one can disseminate details on new and primary increase ments in allergology. the truth that English has develop into the lingua franca at congresses for the alternate of rules in clinical specialties ended in the choice to carry the symposium in English. despite the gentle handicap this posed for a few members, it was once additionally a significant factor within the symposium's luck. This booklet comprises the papers added by way of the invited audio system including the poster displays. They disguise either easy ex perimental examine in addition to medical difficulties in allergology.
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Extra info for New Trends in Allergy
Perelmutter L, Liakopoulou A (1974) Interrelationship of human IgE antibody and allergen in the rat mast cell technique. Int Arch Allergy Appl ImmunoI46:280-288 3. Phills lA, Perelmutter L (1974) IgE mediated and non-IgE mediated allergic-type reactions to aspirin. Acta Allergol (Copenh) 29:474-490 4. Pontefract R, Perelmutter L (1976) An electron microscope study of receptor sites on rat mast cells for human immunoglobulin E. Acta Allergol (Copenh) 31: 184-192 5. Haddad ZH, Lopapa A, Korotzer 1 (1971) Direct demonstration of human immunoglobulin E (IgE) on rat mast cells after passive sensitization in vitro.
Distinction between binding and triggering sites lease. In fact, BPO I was found to specifically inhibit BPOrinduced histamine release, but did not affect the release due to other antigenic stimuli. Dembo, Goldstein and collaborators proposed a hypothetical model of cross linking which may comprise the following reaction steps (Fig. 9). BP0 2 is an example of what has been called a synthetic bivalent hapten. ffll 30 Fig. 9. Bridging hypothesis and possible modes of crosslinking, (according to Dembo and Goldstein 1979 [11 ]) The IgE Receptor identical hapten groups connected by flexible polymer chains.
Nr. Patient Serum IgE cone. L. K. F. L. K. M. 4000 4 6 25 25 5 46 In Vitro Sensitization of Rat Mast Cells Table 2. Histamine release (in %) from sensitized rat cells by rabbit anti-human IgE. L. L. dilution -log2 4 6 positive Rabbit anti-human IgE dilution -log 2 Released histamine in% 3 24 19 22 30 5 38 34 32 21 3 5 27 8 8 10 4 6 8 10 negative 4 2 2 6 Table 3. Histamine liberation (in %) from sensitized rat cells by diluted echinococcus antigen. M. M. human serum 4 5 6 1:64 1:256 19-20 19-19 9-9 12-13 13-17 8-7 From not sensitized cells 17 6 3 Table 4.