By H. Yoshida

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Pharm. , 31^, 558-559. D. (1977). , 21, 563-568. D. (1977). Soc. Neurosci. , 3, 36. R. Carlson (1976). Psychopharmacology, 48, 139-146. , and P. Lundborg (1979). Eur. J. , 60, 393-395. , S. Liljequist, and K. Johannessen (1976). Antipsychotic Drugs. Pharmacodynamics and Pharmacokinetics. G. Sedvall, B. Uvna's and Y. Zotterman, Pergamon Press, Oxford. M. Milner (1977). Pharmacol. Biochem. , 7, 507514. Ezrin-Waters, C , and P. Seeman (1977). Eur. J. , 41, 321-327. Ezrin-Waters, C , and P. Seeman (1978).

1977). 4; 2 5; 3 wks mo. ,1979. ,1980. List & Seeman,1979. ,1978. Marshall & Mishra,1980. ,1977. ,1976. Muller & Seeman,1976,77. ,1978. Leysen,1980. ,1980. ,1980. + 77% + 67% + 58% + 37% + 28% 4- 18% 4- 11% + 17% +300% Muller & Seeman, 1977. ,1978. ,1977. ,1978. List & Seeman,1979. Leysen,1980. ,1980. ,1980. ,1980. 5; 4 wks 3 H-AP0 3H-DA 3 H-DA 3H-ADTN 3H-AP0 3H-AP0 3H-ADTN 3H-NPA 3H-AP0 3 nM Bmax 10 nM Bmax 3 nM 4 nM Bmax Bmax 1 nM Trifluoperazine 3;12 mo. Thioridazine 35;12 mo. 01; 6 days Estradiol H-SPIP Amphetamine Amphetamine Amphetamine Methylphenid.

ACKNOWLEDGEMENTS The research from the authors' laboratory has been supported by USPHS grant MH-29228 and by the Tennessee Department of Mental Health and Mental Retardation. J. K. (19 77). Development of B-adrenergic receptor subsensitivity by antidepressants. Nature, 268, 455-456. P. C. (1976). Modula­ tion in the sensitivity of noradrenergic receptors in the CNS studied by the responsiveness of the cyclic AMP system. Brain Res. 116, 111-124. A. J. (1979a). Adrenergic and serotonergic receptor binding in rat brain after chronic desmethylimipramine treatment.

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