By R. J. Aitken (auth.), Professor Dr. med. Dr. h.c. Thomas Rabe, Professor Dr. med. Klaus Diedrich, Professor Dr. med. Thomas Strowitzki (eds.)

Our wisdom of reproductive drugs has extended quickly because the beginning of Louise Brown, the 1st child to be conceived by way of in vitro fertilization, which was once played by way of Professors Patrick Steptoe and Bob Edwards in Oldham, Eng­ land, in 1978. hardly ever a yr is going by means of with no the advance of a brand new or a amendment of an current approach to assisted copy. inside a comparatively brief interval, in vitro fertilization has been brought into the remedy of lady infertility. Intracytoplasmic sperm injection has additionally created new possibilities for the therapy of male infertility. the 1st version of this ebook used to be released in 1996. within the moment version many of the chapters were up-to-date and extra curiosity is concentrated on intracytoplasmic sperm injection (ICSI) in view of the chance of malformations in newborns. This guide addresses the thoughts of assisted replica which are avail­ capable this day. efficient authors from a variety of facilities current, in a concise approach, their tried-and-tested strategies, in order that the latter could be conveniently carried out. as a result of diversified criminal laws, the scope of assisted copy is way extra restricted in Germany than in lots of different nations. for instance, while in basic terms 3 embryos could be created and transferred in Germany, such restric­ tions don't exist in numerous different ecu international locations and the us. in addition, heterologous fertilization, oocyte donation, and surrogate mom­ hood are banned in Germany.

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If the patient wishes to conceive, stimulation treatment with antiestrogens, gonadotropins, or a GnRH pump should be attempted. In cases of hypogonadotropic amenorrhea, therapy with pulsatile GnRH (GnRH pump) or stimulation with human chorionic gonadotropin (HMG) should be tried. 38 K. Grunwald et al. One from between 200 and 500 adolescent girls suffers from anorexia nervosa. They try to become as slim as possible by fasting. The fasting phases may be punctuated by episodes of voracious eating (bulimia).

All regulatory systems in reproductive biology can act via multiple pathways, so that when one system is lost, another can usually take over its functions. Human beings, currently at the apex of the evolutionary process, show many ontogenic traces of the phylogenic steps involved in the development of the human reproductive system. This pertains both to organ systems and to regulatory mechanisms. Findings in laboratory animals. do not necessarily apply to human beings. Regulatory systems that are of major importance in animals may be demonstrable in humans, but they may make little if any significant contribution to human functioning.

The high-affinity binding sites for GnRH are the actual receptors, while the low-affinity binding sites represent endopeptidases. The GnRH receptor is a glycoprotein (MW 60000) that contains sialic acid residues. It is believed that receptors are distributed uniformly on the cell surface. Once binding occurs, the hormone-receptor complex moves along the cell membrane in a process known as lateral migration. This migration ends at a specialized region called the coated pit. Coated pits are lipid vesicles that are bound to a "basket" of specific latticelike proteins.

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