By Alex P. Mowat

This e-book presents an account of contemporary paediatric hepatology

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By Popper, H. and Schaffner, F. New York: Grune and Stratton BIBLIOGRAPHY 41 Odievre, M. (1976). Breast feeding and neonatal hyperbilirubinaemia. In Liver Diseases in Infancy and Childhood, p. 34. Ed. R. D. (1972). Photochemical and biochemical basis of the treatment of neonatal jaundice. In Progress in Liver Diseases, Vol IV, p. 447. Ed. by Popper H. and Schaffner, F. New York: Grune and Stratton Seigel, S. et al. (1972). Placental transfusion and hyperbilirubinaemia in the premature. L. M. (1975).

R. D. (1972). Photochemical and biochemical basis of the treatment of neonatal jaundice. In Progress in Liver Diseases, Vol IV, p. 447. Ed. by Popper H. and Schaffner, F. New York: Grune and Stratton Seigel, S. et al. (1972). Placental transfusion and hyperbilirubinaemia in the premature. L. M. (1975). Pharmacologic treatment of neonatal hyperbilirubinaemia. ClinsPerineonatal. 2, 37 CHAPTER 4 Conjugated Hyperbilirubinaemia Conjugated hyperbilirubinaemia is always pathological, in contradis­ tinction to unconjugated hyperbilirubinaemia which may be physio­ logical in infancy.

Intravenous nicotinic acid in a dose of 50 mg in the adult also causes a sharp increase in serum bilirubin levels. Such an injection and fasting have been used clinically to support the diagnosis. Males are more commonly affected than females. The age of onset is difficult to determine but most cases come to light at around the age of ten years but there is frequently much delay in diagnosis. Diagnosis Diagnosis should be restricted to patients who have no past history of liver disease, who show no abnormality on clinical examination, except icterus, who have normal haematological studies and liver function tests including normal serum bile acids but do have a persistent documented mild hyperbilirubinaemia.

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