By Kathleen Stratton, Donna A. Alamario, Theresa Wizemann

An infection with the influenza virus could have a major influence at the future health of individuals of every age, even though it is very worrisome for babies, the aged, and other people with underlying center or lung difficulties. A vaccine exists (the flu shot) that could enormously reduce the impression of influenza. as the lines of virus which are anticipated to reason severe sickness and demise are a little bit diverse each year, the vaccine can also be a little bit diversified each year and it needs to be given each year, not like different vaccines. The Immunization safeguard evaluate committee reviewed the knowledge on influenza vaccine and neurological stipulations, and concluded that the proof favorite rejection of a causal courting among influenza vaccines and exacerbation of a number of sclerosis. For the opposite neurological stipulations studied, the committee concluded the proof concerning the results of influenza vaccine is insufficient to just accept or reject a causal dating. The committee additionally reviewed theories on how the influenza vaccine may well harm the fearful procedure. The facts used to be at such a lot vulnerable that the vaccine may act in people in ways in which may lead to those neurological difficulties.

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Extra info for Immunization Safety Review: Influenza Vaccines and Neurological Complications

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The committee does not investigate the sources of funding of the published research reports it reviews, nor do funding sources influence the committee’s interpretation of the evidence. Unpublished data and other reports that have not undergone peer review do have value, however, and are often considered by the committee. They might be used, for example, in support of a body of published, peer-reviewed literature with similar findings. If the committee concluded that the unpublished data were well described, had been obtained using sound methodology, and presented very clear results, the committee could report, with sufficient caveats in the discussion, how the unpublished data fit with the entire body of published literature.

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Basic and Clinical Science Despite improvements over the past 25 years in the broad understanding of the pathogenesis of autoimmune diseases, and of GBS in particular, the exact mechanisms by which the 1976 influenza vaccine precipitated this adverse outcome remain unknown. To gain further insight into these mechanisms, the committee sees a need for additional basic and clinical research on influenza viruses, the composition and immunological properties of the 1976 vaccine, immunological responses to vaccines in general, and host characteristics that may affect susceptibility to adverse events.

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