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21). Example. SIV-Z rats (170 g initial weight) were given the hepatocarcinogen, N-nitrosomorpholine (NNM) (10 mg/100 ml drinking water) for 56 days. " (See Fig. ) 26 υ . BOELSTERLI AND G. 6 ALKALINE PHOSPHATASE STAINING Increased alkaline phosphatase activity is, according to Ekelund,^^ a highly sensitive method for detecting mild bile stasis in smears. ^^ *® The canalicular ATPase and the cytoplasmic G-6-Pase can easily be demonstrated by cytochemical methods (Fig. 11). However, as mentioned above, care must be taken in interpreting the results, as enzyme activity fluctuates in the rat Uver as to the site of the cells investigated within a hepatic lobule.

1975) Drug-induced phospholipidosis. CRC Critical Reviews in Toxicology 4,185-218. 8. PITOUT, M. J. (1968) Effect of ochratoxin A on glycogen storage in the rat liver, ToxicoL Appl. Pharmac, 13,299-306. 9. REUBER, M. D. (1969) Thyroiditis in rats given subcutaneous injections of trypan blue, Toxicol. Appl. Pharmac, 14,108-113. 10. ROUILLER, CH. (1964) Experimental toxic injury of the liver. The Liver, Morphology, Biochemistry, Physiology (Edited by ROUILLER) Vol. IL Academic Press, New York and London, 1964, pp.

30. , A. LUNDQUIST and O. LUNDVALL (1969). Evaluation of fine-needle aspiration biopsy smears in the diagnosis of liver iron overload. Acta Med. Scand. 186,369-373. 31. LUNDQUIST, A. (1970). Fine-needle aspiration biopsy for cytodiagnosis of malignant tumour in tiie liver. Acta Med. Scand. 188,465-470. 32. LUNDQUIST, A. (1970). 7 mm outer diameter. Acta Med. Scand. 188,471-474. 33. LUNDQUIST, A. (1971). Fine-needle aspiration biopsy of Üie Uver. Acta Med. , Suppl. 520. 34. LUNDQUIST, A. and M. AÍKERMAN (1970).

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