By Hans Schreier

Demonstrates how substitution of various ligands can render albumin a flexible focusing on software for selective drug accumulation in quite a few telephone populations of the liver! This e-book discusses actual, chemical, and organic methods to drug concentrating on expertise, targeting oral, dispersed procedure, topical, dermal, transdermal, and inhalation supply, and the improvement of unique formulations which are matched by way of cutting edge machine layout. Considers the efforts in biotechnology and molecular biology to provide clever drug supply units by way of exploiting organic pathways! Containing over 1100 references to facilitate additional learn, Drug focusing on expertise ·updates fresh growth in oral and colonic focusing on expertise utilizing pH- and enzyme-sensitive coating fabrics and novel polymer platforms ·shows how the systemic distribution of substances may be modulated by means of lipid-based companies taking alternative ways of shipping, rather lymph stream ·details smooth medicinal drugs which are swiftly metabolized to inactive and unhazardous metabolites and got rid of successfully from the physique ·includes profitable designs of virus-like liposomal supply platforms that provide the benefits of viral providers ·supplies examples of the way viral supply platforms could be directed to melanoma websites ·and extra! Suggesting harnessing organic strategies because the final method of the supply or expression of pharmacologically lively brokers, Drug focusing on expertise is a top-shelf reference for pharmacists, pharmacologists, and pharmaceutical scientists; analytical, floor, actual, and colloid chemists and biochemists; and upper-level undergraduate and graduate scholars in those disciplines.

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Extra info for Drug Targeting Technology: Physical, Chemical and Biological Methods (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs)

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Clin. Pharmacol. 30:95–97 (1986). 6. A. H. Staib, B. G. Woodcock, D. Loew, and O. Schuster, Chapter 8: Remote control of gastrointestinal drug delivery in man (L. F. Prescott, and W. S. ), Novel Drug Delivery and Ist Therapeutic Application, J. Wiley & Sons, Chichester, UK, 1989, pp. 79–88. Coating Materials for Colon-Specific Delivery 45 7. H. Laufen, and A. Wildfeuer, Absorption of isosorbide-5-nitrate from the gastrointestinal tract (N. Riethbrock, B. G. Woodcock, A. H. Staib, and D. ), Methods in Clinical Pharmacology, Vol.

B. C. Lippold, B. H. Lippold, Physibalisch-chemisches Verbalten von polymethacrylsauve derivation, Pharm Ind 35:854ff (1973). 73. P. H. List, G. Kaosio, Water vapor and oxygen permeability of various tablet coatings, Acta Pharm Techn 28(1) 1982. 2 New Experimental Coating Material for Colon-Specific Drug Delivery Kurt H. Bauer Freiburg Materials Research Center, Freiburg, Germany I. INTRODUCTION Colonic targeting has gained increasing interest over the past years. A considerable number of publications dealing with colon targeting, colon-specific drug delivery, and absorption from the cecum and other colon sections indicates a growing focus of research activities in this area.

Enteric targeting may also include other, new dosage forms, which remain located in the stomach and start releasing their drug from there. These gastricretention systems consist of a swellable core, usually film coated with highly flexible polymers that disintegrate after a certain time of ‘‘floating’’ in the stomach. Deshpande et al. [71] have described such a system recently. Enteric targeting will gain more importance as biotechnological products Enteric Coating 25 like proteins, hormones, and vaccines become available at reasonable cost and for a larger number of patients.

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