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I. The influence of urinary pH and urine volume output. J. Pharmacol. exp. Ther. : Comparative metaboIism of some amphetamines in various species. , Snyder,S. ): Frontiers in Catecholamine Research, Pergarnon Press, Oxford, pp. : Self-administration of optical isomers of amphetamine and methylamphetamine by rats. J. Pharmacol. exp. Ther. 187,27-33 (1973) Zirkle, C. : Monoamine oxidase inhibitors (nonhydrazines). 474. New York: Academic Press 1964 B. LEWANDER A. Introduction The present seetion of this review is subdivided into two major parts; the first part being eoneerned with the bioehemical neuropharmacology, and the second part dealing with the modes and sites of action for the various peripheral and central effects of amphetamine.

The most extensively investigated drug, both in animals and man is amphetamine. p. , 1969). , 1969; LEwANDER, 1971 b). , 1971). , 1969; LEwANDER, 1971 b; JONSSON and LEwANDER, 1973). A comparative study of the pharmacokinetics of amphetamine in domesticated animals was performed by BAGGOT and DAVIS (1973). These authors concluded that a relationship existed between dietary habit of different animals and the elimination Pharmacokinetics and Metabolism 21 rate and metabolie pattern of amphetamine.

1965) or hyperthyroid (MooRE, 1965) mice. Rabbit: The concentration of NA in the superior cervical ganglion decreased to 70% ofthe controllevel in the experiments by SAN AN and VOGT (1962). Guinea Pig: Beart NA decreased to 65% of the control level 4 h after 20 mg/kg dl-amphetamine (LEWANDER, 1971 c). Chronic treatment of guinea pigs with this dose twice daily for 18 days caused an additional decrease to 52% of the control level. v. , 1972; GLICK et al. , 1973, 1974). The decrease in brain NA is dose dependent (MooRE and LARIVIERE, 1963; BAIRD and LEWIS, 1964; LEONARD and SHALLICE, 1971).

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