By R. Knippers, J. Ruff (auth.), Prof.Dr. Ellen Fanning, Prof.Dr.med. Rolf Knippers, Prof.Dr. Ernst-L. Winnacker (eds.)

Provided this is an simply obtainable creation to the mechanisms of DNA replication, legislation and the biochemistry of telephone cycle regulate. an summary of this speedily constructing box is gifted to orient the reader, via a sequence of contributions by way of best researchers summarizing contemporary effects on chosen themes, akin to protein phosporylation, tumor suppressor genes, and sign transduction in prokaryotic and eucaryotic platforms. The reader will achieve an summary of our present knowing of DNA replication and the phone cycle, and a range of helpful fresh references for additional reading.

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Additional info for DNA Replication and the Cell Cycle: Colloquium der Gesellschaft für Biologische Chemie, 9.–11. April 1992 in Mosbach/Baden

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EMBO J 8:2393-2402 Mensa-Wilmot K, Seaby R, Alfano C, Wold MS, Gomes B & McMacken R (1989b) Reconstitution of a nine-protein system that initiates bacteriophage i.. DNA replication. J BioI Chem 264:2853-2861 Sanger F, Coulson AR, Hong GF, Hill OF & Petersen GB (1982) Nucleotide sequence of bacteriophage ADNA. J Mol Bioi 162:729-773 Schnos M, Zahn K, Inman RB & Blattner FR (1988) Initiation protein induced helix destabilization at the i.. origin: a prepriming step in DNA replication. Cell 52:385-395 Thomas R & Bertani L (1964) On the control of the replication of temperate bacteriophages superinfecting immune hosts.

Those A and E. coli proteins identified by genetic and biochemical studies as being probable participants in A DNA replication were purified to near homogeneity (Fig. 2; Mensa-Wilmot et al. 1989b). As indicated in Table I, a combination of nine phage- and bacterial-encoded proteins was found to be sufficient to support replication of supercoiled oriA plasmid DNA (Mensa-Wilmot et al. 1989b). Omission of any of these proteins from the system led to a striking reduction in the level of A DNA synthesis.

Science 245 :385-390 Fuller RS, Kaguni 1M & Kornberg A (1981) Enzymatic replication of the origin of the Escherichia coli chromosome. Proc Natl Acad Sci USA 78:7370-7374 Furth ME, Dove WF & Meyer BJ (1982) Specificity determinants for bacteriophage A. DNA replication. ill. rI"C mutants by transcription outside of ori. J Mol BioI 154:65-83 Inman RB & Schnos M (1970) Position of branch points in replicating A. DNA. J Mol BioI 51:61-73 Landry SJ, Jordan R, McMacken R & Gierasch LM (1992) Different conformations for the same polypeptide bound to chaperones DnaK and GroEL.

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