By Tushar K. Chowdhury (auth.), Tushar K. Chowdhury, A. Kurt Weiss (eds.)

Concanavalin A (Con A), a plant lectin, has turn into an item of intensive study not just for the biochemist, but in addition for the bi­ ologist, biophysicist, pathologist, immunologist and others. On April 19-20, 1974 a gaggle of students from 4 continents met at the campus of the college of Oklahoma for a world Symposium on Con A. This quantity includes all lectures provided by way of the invited audio system in this celebration, in addition to the abstracts for all shorter technical papers that have been provided. extra, the edi­ tors invited extra contributions from a number of chosen laboratories to hide the components no longer lined within the symposium itself. This quantity then studies the current prestige of study with Con A. In a feeling it really is encyclopedic and will be an invaluable reference device to the employee during this box. The newcomer to this sector will locate cautious examine of this ebook will carry him up to date with the most recent thoughts, ap­ proaches and the "state of the artwork" during this really good region of re­ seek, in addition to with traps and ensnarements within which he needn't become involved back. beginning on the molecular point and advancing from there to the organismic point in addition to to a couple of hugely really good components, this quantity provides the main entire survey of study findings with Con A to be had this day. The editors desire to recognize the beneficiant monetary help supplied by way of the collage of Oklahoma via its President, Dr.

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II. , 1973). These include glycoprotein, glycolipids and mucopolysaccharides. To be complete one should also include nucleic acids, sugar nucleotides and other, per- CON A COMBINING SITES 37 Fig. 1. An a-D-mannopyranosyl residue. Underlined atoms are believed to be involved in hydrogen bonding with the protein. , polysaccharides). The simple sugars which occur as building units of these substances include the pentoses,D-xylose, D-ribose, and perhaps L-arabinose; the hexoses, D-glucose, D-mannose and D-galactose; the deoxy sugars, L-fucose (6-deoxy-L-galactose) and 2-deoxy-D-ribose; the hexosamines~N-acetyl-D-glucosamine and N-acetyl-D-galactosamine and the uronic acid~ D-glucuronic acid and L-iduronic acid.

A... 1 r G Fig. 8. Distribution of fluorescein-labelled anti-immunoglobulin on mouse splenic lymphocytes, illustrating diffuse staining (A), patches (B), and caps (C). Cap formation is prevented by Con A, but not by succinyl-Con A. higher doses, the response to native Con A decreases much more rapidly than that to succinyl-Con A. This difference seems to be correlated with decreased cell viability at high doses of native Con A. Succinylation of Con A also alters its immediate effects on the lymphocyte surface, as assayed by the modulation of cell-surface receptor mobility.

Et Biophys. Acta 336, 46. 3 STUDIES ON THE COMBINING SITES OF CONCANAVALIN A I. J. Goldstein University of Michigan Ann Arbor, Michigan, U. S. A. ABSTRACT The initial event in. the biological activity of concanavalin A (Con A) involves binding of the protein to cell surface receptors. The nature and mechanism whereby such binding may occur is described in terms of cell surface carbohydrates and the demonstrated specificity of the protein. Although considerable latitude is tolerated at the C-2 position of the a-D-hexopyranose ring system, the carbohydrate binding site of Con A appears to be complementary to a-Dmannopyranosyl residues.

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