By Nancy J. Rusch, William J. Stekiel (auth.), Robert H. Cox (eds.)

Hypertension is famous to be one of many significant possibility components for the advance of peripheral vascular affliction. the decade has witnessed numerous significant advances in remedy for high blood pressure, together with the advance of angiotensin-converting enzyme inhibitors and calcium channel blockers. those compounds have significantly greater the power to regulate blood strain and to lessen the impression of this hazard issue on morbidity and mortality. regardless of those advances, heart problems is still an enormous sickness in most up-to-date industrialized international locations with similar deaths exceeding these from all different explanations mixed. unlike those advances in remedy, our figuring out of the fundamental mechanisms liable for the pathogenesis of high blood pressure continues to be incomplete. contemporary reviews have produced new insights into the character of the rules of muscle contraction in either center and blood vessels in addition to the adjustments in muscle functionality that ensue in high blood pressure. besides the fact that, the consequences of antihypertensive treatment, either by way of restoring general functionality and in generating reversal of hypertension-associated alterations, has no longer been as completely studied, particularly within the vasculature. experiences within the middle recommend that the efficacy of alternative healing brokers in restoring general functionality and reversing hypertensive alterations fluctuate considerably with the mechanism of motion of the healing agent. It has additionally been lately decided that a few healing brokers produce opposed results on plasma lipid profiles, that could result in the secondary acceleration of the atherosclerotic approach, whereas whilst normalizing blood pressure.

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EFFECTS OF ANTIHYPERTENSIVE DRUGS ON THE ARTERIAL WALL Certain antihypertensive agents, particularly beta adrenergic blockers and calcium antagonists, have been shown to reduce the rate of development of atherosclerosis in cholesterol-fed normotensive animals (2831). The mechanism for the anti-atherogenic effect of any of these antihypertensive drugs is unknown although all are obviously capable of lowering blood pressure or may otherwise change the hemodynamic stresses on the arterial wall. Despite their favorable effects on atherogenesis in the cholesterol-fed animal models, beta blockers and calcium antagonists have failed as yet to affect atherosclerosis in the WHHL.

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