By Eugene C. Toy, Jr., William E Seifert, Henry W. Strobel, Konrad P. Harms

Fifty medical situations assist you excel in biochemistry classes and the USMLE Step 1

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Additional resources for Case Files: Biochemistry (Lange Case Files), 2nd edition

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Dihydrofolate reductase: The enzyme that reduces folic acid (folate) first to dihydrofolate and then to the active tetrahydrofolate. Dihydrofolate reductase uses NADPH as the source of the reducing equivalents for the reaction. Folic acid: An essential vitamin composed of a pteridine ring bound to p-aminobenzoate, which is in an amide linkage to one or more glutamate residues. The active form of the enzyme is tetrahydrofolate (THF, FH4), which is an important carrier of 1-carbon units in a variety of oxidation states.

What is the molecular basis for the large erythrocytes? 36 CASE FILES: BIOCHEMISTRY ANSWERS TO CASE 4: FOLIC ACID DEFICIENCY Summary: 47-year-old alcoholic white female has fatigue, malaise, nausea, vomiting, and poor nutritional intake with macrocytic anemia and no evidence of pancreatitis, liver disease, or peptic ulcer disease. ◆ ◆ Cause of anemia: Folic acid deficiency. Molecular basis of macrocytosis: Abnormal proliferation of erythroid precursors in the bone marrow, since folate deficiency encumbers the maturation of these cells by inhibition of deoxyribonucleic acid (DNA) synthesis.

Ribavirin incorporation is mutagenic, because it serves as a template for incorporation of cytidine and uridine with equal efficiency (Figure 2-2). 00001 percent in cell culture. The antiviral activity of ribavirin correlates directly with its mutagenic activity. ” This study reveals a new concept about nucleoside analogs, that is, mutagenic ribonucleosides may represent an important class of anti-RNA virus agents. RNA viruses like HIV and the influenza virus use a naturally high mutation rate of their RNA polymerases with low fidelity for replication to avoid and escape most treatments and vaccines.

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