By Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath
Background Lesions in Laboratory Animals might be a useful relief to pathologists desiring to acknowledge historical past and incidental lesions whereas studying slides taken from laboratory animals in acute and protracted toxicity reports, or whereas analyzing unique species in a diagnostic laboratory. It offers transparent descriptions and illustrations of nearly all of historical past lesions more likely to be encountered. a number of the lesions coated are strange and will be improper for treatment-related findings in preclinical toxicity studies.
The Atlas has been ready with contributions from skilled toxicological pathologists who're experts in all the laboratory animal species lined and who've released greatly in those areas.
- over six hundred high-definition, most appropriate colour pictures of heritage lesions present in rats, mice, canines, minipigs, non-human primates, hamsters, guinea pigs and rabbits
- a separate bankruptcy on lesions within the reproductive platforms of all laboratory animals written by means of Dr Dianne Creasy, a global professional on testicular lesions in laboratory animals
- a bankruptcy on universal artifacts that could be saw in histological glass slides
- extensive references to every lesion described
- aging lesions encountered in all laboratory animal species, relatively in rats in mice that are used for carcinogenicity studies
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Additional info for Background Lesions in Laboratory Animals. A Color Atlas
35, 735–740. 142 Auricular chondritis in the rat ear with cartilage degeneration and mineralization. ×100. , 1996. Non-proliferative lesions of the alimentary canal in rats. In: GI-1 guides for toxicologic pathology. STP/ ARP/AFIP, Washington DC. , 1990. Lung. , et al. ), Pathology of the Fischer rat. Academic Press, San Diego, pp. 339–367. , 1990. Oral cavity, esophagus, and stomach. , et al. ), Pathology of the Fischer rat. Academic Press, San Diego, pp. 9–29. , 1978. Pathology of aging rats.
42) is a congenital lesion generally involving the incisor teeth and it may be related to malocclusion or food impaction (Fig. 43) (Monticello et al 1990). Dental dysplasia is the abnormal development of odontogenic tissues (Bertram et al 1996). Dental dysplasia is often observed in conjunction with inflammation and trauma. The lesion consists of a large mass of dentine-like material with fragments of tooth and bone (Bertram et al 1996). Cleft palate is a congenital lesion encountered in the midline of the hard palate of rats (Renne et al 2009).
71–92. , 2004. Androgen and estrogen receptors expression in the rat exorbital lacrimal gland in relation to “harderianization”. J. Exp. Zool. 301A, 297–306. , 2007. The rat. C. ), Animal models in toxicology, second ed. Taylor & Francis, Boca Raton, pp. 147–217. , 2009. Eosinophilic inclusions in rat Clara cells and the effect of an inhaled corticosteroid. Toxicol. Pathol. 37, 315–323. , 1969. Melanotic lesions of the eye in August hooded rats induced by urethan or N-hydroxyurethan given during the neonatal period: a histopathological study.