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Expression of different mucins, deﬁned by differences in either their protein backbones or their glycosylation patterns, has been shown to vary both between and within tissues, and during intestinal ontogenesis. Mucin molecules are assembled and stored in large, membrane-bound granules before secretion from the goblet cells. Secretory mucins are secreted from the apical surface of the goblet cells by either baseline secretion or compound exocytosis. , 1995). An investigation of the ontogenesis and development of mucin-producing 36 Z.
Com 2Departament ABSTRACT The mucosal epithelium of the small intestine constitutes a highly dynamic interface with the external environment through the delivery, digestive processing and absorption of nutrients. The intestinal mucosa is capable of rapid and extensive morphological and functional adaptation in response to evolutionary changes, genetic selection, altered dietary composition or food availability and pathological processes. The function of the intestine and adaptations therein may be studied at the molecular, cellular, organic or whole animal level, employing a variety of in vitro and in vivo techniques.
An increasing gradient of goblet cell density was observed along the duodenal–ileal axis. Thus, the development of small intestinal mucous-secreting cells in chicks occurs in the late embryonic and immediate post-hatch period. , 2004) revealed a sustained increase in mucin mRNA expression from 17E to day 3 post-hatch, at which point expression stabilized. This increase in mucin mRNA levels parallels the increase in the number of goblet cells occurring from the late incubation stage through the ﬁrst week posthatch.